The most supreme among the top ten alchemy masters of the Nine Provinces, while refining the number one divine artifact of the Nine Provinces—the Void Yin-Yang Cauldron—was unexpectedly struck down by thirteen bolts of Void Yin-Yang Tribulation. Yet, because of the true secret of this number one divine artifact, he was reborn. What he didn't expect was to be reborn into the body of the so-called number one scourge of Yunge City, the top profligate of Yunge City.

From then on, the life of an arrogant wastrel begins, pursuing the ultimate peak of alchemy and forging the legend of the Immortal Pill God.